Making television history, Pose features the largest cast of transgender actors in series regular roles, as well as the largest recurring cast of LGBTQ actors ever for a scripted series. The transgender cast includes Mj Rodriguez, Dominique Jackson, Indya Moore, Hailie Sahar and Angelica Ross, who co-star alongside Evan Peters, Kate Mara, James Van Der Beek, Tony award-winner Billy Porter, Charlayne Woodard, and newcomers Ryan Jamaal Swain, Dyllón Burnside and Angel Bismark Curiel.

Evan Peters and Kate Mara play New Jersey couple Stan and Patty Bowes, who get sucked into the glamour and intrigue of New York City in the 1980s, as epitomized by Matt Bromley (James Van Der Beek), Stan’s boss. Mj Rodriguez stars as Blanca Rodriguez, who breaks from the House of Abundance and her former house mother Elektra Abundance (Dominique Jackson) to form her own 'house', a self-selected family that provides support to LGBTQ youth rejected by their birth families.

Indya Moore plays Angel, a streetwalker who develops feelings for her new client, Stan. Ryan Jamaal Swain plays Damon Richards, a dancer who joins Blanca’s house. Together they compete in the Balls - where house members challenge each other in various categories and are judged on their outfits, attitude, or dance skills. Under the watchful eye of Pray Tell (Billy Porter), Grandfather to all the children who compete in the house balls, Elektra’s House of Abundance and Blanca’s upstart House of Evangelista face off in what may develop into a legendary rivalry.

Pose was co-created by Ryan Murphy, Brad Falchuk and Steven Canals.