Lady Gaga has taken a stab at some of her critics in a series of defiant Twitter messages.

The singer is often the target of negative hate but she took aim at it all last night (October 20) as she discussed subjects such as Madonna comparisons, drug use and her weight.

She opened: "LADY GAGA IS FAT NOW! #DoWhatUWantWithMyBody."

The 'Applause' star added: "LADY GAGA IS A REDUCTIVE MADONNA COPY! SHE'S OVER NOW! #WriteWhatUWant #SayWhatUWantBoutMe #ImNotSorry."

Gaga then mentioned rumours that she is a hermaphrodite, her battle with drug addiction and her relationship with God before saying:

"APPLAUSE didn't DEBUT AT #1! KATY IS BETTER THAN HER! #UWontUseMyMind I write for the music not the charts."

The singer meanwhile has just released her new R. Kelly duet 'Do What U Want', which is the latest track to be taken from her upcoming album 'ARTPOP'.

The record is due to hit shelves on November 11 as she follows up 2011's 'Born This Way'.